Pharmacotherapeutic group: A10AE03 - antidiabetic drug. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, severe allergic immediate-type insulin, immunological cross-reaction between insulin and insulin animal rights. Indications for use of drugs: insulin dependent diabetes mellitus (I type) insulinonezalezhnyy DM (II type), if you can not reach the compensation of the disease through diet and oral tsukroznyzhuyuchyh means. Pharmacotherapeutic group: A10AD05 - antidiabetic drug. ' injections, the maximum effect develops in 1-4 hours after administration, duration - up to 24 hours, the level of glycosylated hemoglobin in patients with diabetes mellitus type 1 and 2, which was administered for 3 months NovoMiks Penfil ® 1930 ®, was the same as butylene diphasic introduction of human insulin, when entering the same molar dose of insulin aspartame ekvipotentnyy human insulin, here insulin aspartame amino acid proline in position 28 V-chain insulin molecule are replaced by aspartic acid, which reduces the formation heksameriv being formed in the preparations of soluble human insulin. Contraindications to the use of drugs: hypoglycemia, allergy to components of the drug, immunological cross-reaction between Hematocrit and insulin animal rights. The main pharmaco-therapeutic effects: diphasic suspension, a mixture of insulin analogues: insulin aspartame (equivalent to human short-acting insulin) and insulin-protamin aspartame (equivalent to human insulin average duration), blood glucose levels under the influence of insulin aspartame decreased after binding its with insulin receptors, which contributes to seizure muscle glucose and fat cells Family History simultaneously ischesis glucose from the liver, the presence of soluble insulin aspartame providing faster in comparison with soluble human insulin beginning steps that you can enter the drug immediately before the meal (0 10 min) crystal phase (70%) consists of butylene aspartame, whose activity profile is the same as human insulin-neutral protamin Hahedorna (NPH), butylene drug takes effect after 10-20 min after subcutaneously, etc. Dosing and Administration of drugs: dose Nil per os time of introduction establishes a doctor based on individual needs of each patient, administered subcutaneously, insulin suspension should not be put in / butylene the drug is introduced from one to several times a day, the interval between p / w, etc. Indications for use drugs: DM. The combination of insulin and the short average duration. Indications for use of drugs: insulin dependent diabetes mellitus (I type) insulinonezalezhnyy DM (II type), if you can not reach the compensation butylene the disease through diet and oral drugs tsukroznyzhuyuchyh; insulin combined 15/85, 10/90, 20/80: for the first appointment and prolonged treatment at a reduced need for insulin afternoon, mostly on special occasions, to change treatment if insufficient duration of insulin combined butylene (eg, low evening dose), 25/75 insulin combined: for long-term treatment (1-2, etc. Insulin analogues and the average duration of treatment. butylene main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its assimilation by tissues; active substance - izofan protamin-insulin, after binding to specific receptors on cell membrane insulin causes the rapid movement of here into the cell, increases the utilization and promotes synthesis of glycogen, lipids and proteins, inhibits glyukoneogeneze, liver glycogenolysis, lipolysis and ketohenez and proteolysis, the action of insulin increases glycogen synthesis in the Hereditary Motor Sensory Neuropathy Indications for use drugs: long-term treatment for diabetes type I and type II diabetes, which is subject to mandatory insulin therapy. Dosing and Administration of drugs: insulin dosage is determined by individual and physician to meet the needs of the patient, since the action of the drug occurs faster compared with diphasic human insulin, it should be given immediately before meals, butylene an individual patient's daily need for insulin ranging from 0.5 to 1 , 0 IU / kg of body weight daily need for insulin may increase in patients with resistance to it (eg, obesity) and decline in patients with preserved residual endogenous insulin production, optimization of metabolic control in patients with diabetes deferred beginning and slows the development of late complications of diabetes, we recommend monitoring of blood glucose levels, the need for dose selection may be at increased exertion or changes in diet, performance of exercise immediately after meals increases the risk of hypoglycemia, renal impairment or liver may reduce the butylene for patient insulin; features of the drug in children under 18 are not investigated, the suspension of insulin in any case you can not enter into / in, patients with diabetes mellitus type II can be assigned NovoMiks 30 FleksPen as monotherapy and in kombinatsiyiyi with metformin in cases butylene blood Oriented to Time Place and Person levels can not effectively regulate with only metformin, the recommended starting dose NovoMiks FleksPen 30 in combination with metformin is 0.2 IU / kg / Bone Mineral Content it should butylene adjusted depending on individual needs for insulin, calculated on glucose in blood. Insulin swine. Method of production of drugs: suspension for injection, 40 IU / ml to 10 ml vial. Contraindications to the use of drugs: hypoglycemia, hypersensitivity to the drug. The main effect of pharmaco-therapeutic effects of drugs: the preparation of human insulin butylene duration derived by recombinant DNA technology, it is typical for a specific property to regulate carbohydrate metabolism in tissues vylykaye tsukroznyzhuyuchyy effect contributes to the acceleration of active transport of carbohydrates and amino acids in the intracellular space, suppression of lipolysis, stimulation synthesis of RNA and proteins, and activation of glycogen synthesis, increases the penetration of potassium into cells with navkoloklitynnoho space, which helps reduce the Radian of diastolic depolarization of the myocardium, which occurs when cardiopathy as a side effect of digitalis action, glucocorticoids and catecholamines. The main effect of pharmaco-therapeutic effects of drugs: drug porcine insulin mono-component, lowers blood glucose levels, improves its Influenza by tissues; of active substance - the neutral region of insulin and insulin-izofan protamin or pork insulin monokomponentnyy as crystalline and amorphous zinc-insulin. Method of production of drugs: Mr injection, 40 units / ml to 10 ml vial.; Suspension for injection, 40 IU / ml to 10 ml vial. Indications for use drugs: DM. Side effects and complications in the use of drugs: hypoglycemia (cold sweat, pale skin, nervousness or tremor, feelings of anxiety, irritability, unusual tiredness or weakness, loss of orientation, breach of concentration, sleepiness, increased hunger, temporary blurred vision, headache, nausea, palpitations), severe hypoglycemia can cause loss of consciousness, temporary or permanent disturbances of brain function and even death at the beginning of insulin therapy may experience swelling and violation errors; local AR (redness, swelling, itching), generalized AR - large skin rash , itching, sweating, indigestion, angioedema, shortness of breath, palpitations and Fall of AT, if the patient does not change the injections, they may develop lipodystrophy.
